The 22nd Regiment Virginia Cavalry, also known as Bowen's Regiment Virginia Mounted Riflemen was organized on 27 October 1863, with ten companies.The 22nd was was raised by Colonel Henry S. Bowen, former Colonel of the 188th, Tazewell County Militia. Companies 'A' & 'E' of the regiment previously served in William Baldwin's Squadron Virginia Partisan Rangers, therefore some men served for the most or the duration of the war. The 22nd was one of the last Confederate cavalry units to be raised in Southwest Virginia.  This unit served in W. L. Jackson's and McCausland's Brigade and confronted the Federals  in Tennessee, western Virginia, and the Shenandoah Valley. The 22nd Cavalry disbanded in April 1865.  Field officers were: Colonel Henry H. Bowen, Lieutenant Colonel John T. Radford, and Major Henry F. Kendrick.	Brig. Gen.  William L. Jackson	Brig. Gen. John McCausland

Company A: Captain Abram Fuller's Company, was formerly Captain Henry F. Kendrick's Company, and Company B, Baldwin's Squadron. This company was formed by part of Baldwin's Squadron before 1 February 1863. Some of these men had enlisted as early as 4 August  1862. Men from this company were from Russell, Scott, and Washington Counties.

Company B: Captain Gordon W. Rife's Company (Previously Company F(2), 21st Battalion, Infantry and for a short time Company F(1),64th Virginia Mounted Infantry. It is not known exactly when the formation took place. The personnel were mainly residents of Buchanan County. Rife had previously served in the 34th Battalion Virginia Cavalry. It is presumed he was to amass deserters from the 34th Regiment.

Company C: Captain John C. Stanfield's Company was organized on 13 August 1863 in Washington County. Captain Stanfield had previously served in Baldwin's Squadron. This company was formed mostly from men residing in Washington County.

Company D: Captain Martin Ball's Company, was organized 1 May 1863. The company included some men who formerly had served in the 37th Virginia Infantry. The preponderance of the men enlisting into this company lived in Russell County.

Company E: Captain Reese M. Baldwin's Company originally served in Baldwin's Squadron. The original company, (Captain William M. Baldwin's Company), was mustered into Confederate service on 4 August 1862. Most of these men where from Russell and Washington   Counties.

Company F: Was Captain William Washington Brown's Company. This company was organized by 8 August 1863 and were men from Tazewell County.

Company G: Captain William O. Moore's Company was organized 1 August 1863, primarily from residents of Wythe County, with significant numbers from Carroll, Grayson, and other surrounding counties.

Company H: Captain Balaam W. Higginbotham's Company, formed by former members of the 188th Militia of Tazewell County, in which Higginbotham was a captain. The date of organization of this company was 15 August 1863. Most members of this company were residents of Tazewell County, Virginia. Some were from Smyth County.

Company I: Captain William P. Samples Company was organized 15 August 1863, with Russell and Tazewell Counties furnishing almost equal numbers to this group.

Company K: Was Captain William P. Samples' Company. This group was  organized 15August  1863 from men residing in Russell and Tazewell Counties.